Finally, to obtain perillyl alcohol in a pure form, reversedphase highperformance. Perillyl alcohol is a chemical found in certain plants such as lavender and citrus fruits. Safety data sheet septihol sterile sterile alcohol solution. Js material safety data sheet ethyl alcohol 140 proof 1. Safety data sheet behenyl alcohol 4246% date prepared. Subscribe to our newsletter to keep up to date on our latest flavors and fragrances offerings. Transport information land transport us dot no data available. Buy perillyl alcohol cas 18457551, a monoterpene that induces apoptosis in colon tumor cells, from. To concentrate perillyl alcohol of the waterphase in the previous partition step, a glass column 2. Among them, perillyl alcohol poh is a promising anticancer agent that can be produced by hydroxylation of limonene. Synthesis of perillyl alcohol via liquid phase rearrangement of 2,10epoxypinane catalyzed by morpholinium nitrate.
It has a number of manufacturing, household, and medical applications. The o and m menthanes are much rarer, and presumably arise by alkyl migration of pmenthanes. It is also used for cancers that dont seem to respond to treatment perillyl alcohol is sometimes applied directly to the skin as a mosquito repellent. Identification of substance i mixture and of supplier product identifier. Introduction sperillyl alcohol poh, also known as pmetha1,8diene7ol or 4isopropenyl cyclohexene carbinol is a monoterpene produced by a number of plants, including cherries, lavendin, mints, and celery seeds via oxidative modification of dlimonene. The chemfaces provides natural product msds of perillyl alcohol. The identification of perillyl alcohol glycosides with. Perillyl alcohol is a monoterpene found in various plant and fruit sources.
Skin repair properties of dlimonene and perillyl alcohol in murine models. Perillyl alcohol memorial sloan kettering cancer center. For additional guidance, contact the state water board or the 4. Separation of perillyl alcohol from korean orange peel by. Medical interest in this compound was generated by research findings showing that poh was able to inhibit the growth of tumor cells in cell culture and exert cancer preventive and therapeutic activity. Identification product identifier 70% isopropyl rubbing alcohol synonyms isopropyl alcohol. A facile route to perillyl alcohol poh differential glycosylation and the corresponding synthesis of a set of 34 poh. For eye contact, flush with running water for at least 15 minutes. Boiling point vapor density air1 vapor pressure evaporation rate nbuac1 emergency first aid. Isopropyl alcohol 40 70 67630 2006617 fx i 16 67 2000 mgkg rat 5000 ppm 1 hour rat accordance with state, local and federal regulations. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a.
Material safety data sheet isopropyl alcohol 70% issue date april 4 th, 2014 the product has been classified in accordance with the hazard criteria of the controlled products regulations and the msds contains all the information required by the controlled products regulations. Mds098003z manufacturer stock numbers mds098003z recommended use na uses advised against na manufacturer contact address medline industries, inc. India hazel mercantile limited for information in the india, call. Showing metabocard for perillyl alcohol hmdb0003634. People take perillyl alcohol for cancer including lung cancer, breast cancer, colon cancer, prostate cancer, and brain cancer. Stop the flow of material, if this is without risk. Product and company identification ghs product name. Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin. Accidental release measures stop leak if without risk. Perilla aldehyde can use in formula of fragrance, cosmetics and food.
Preclinical development and clinical use of perillyl. Material safety data sheet msds isopropyl alcohol product identification product name. Most important symptoms and effects, both acute and delayed harmful if swallowed. Msds contains all the information required by the cpr. Cytotoxicity is thought to be induced through the endoplasmic reticulum stress pathway. Perillyl alcohol, or poh, a monoterpene derived from the mevalonate. Perillyl alcohol poh is a naturally occurring dietary monoterpene isolated from the essential oils of lavender, peppermint, and other plants. Hunan shifan daxue ziran kexue xuebao 2006, 291, 56.
Perillyl alcohol monoterpene alcohol, limonene chapter pdf available in enzymes 36 december 2014 with 1,485 reads how we measure reads. Showing metabocard for perillyl alcohol hmdb0003634 human. Thus, perillyl aldehyde is considered to be an isoprenoid lipid molecule. Show this safety data sheet to the doctor in attendance. Summary a less known but very effective natural anti cancer element, perillyl alcohol is isolated from the essential oils of several plants including citrus, cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, etc. Perillyl alcohol poh for brain tumors via nasal spray. Do not handle until all safety precautions have been read and understood. Perillyl alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl aldehyde is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Showing metabocard for perillyl aldehyde hmdb0003647. In the presence of iron salts, thermal decompositon can occur, whicn in some cases can become explosive. It has been shown to be cytotoxic to tmzsensitive and tmzresistant glioma cells. Perillyl alcohol can be found in the essential oils of various plants, such as lavender, lemongrass, sage, and peppermint.
Scientific opinion on flavouring group evaluation 208 revision 2 fge. The lack of genotoxic effect across the long chain fatty alcohol reflect that none of. Kleanstrip denatured alcohol material safety data sheet 14. Perillyl alcohol poh is a natural substance called a monoterpene, isolated from the essential oils of lavender, peppermint, spearmint, cherries, celery seeds, and several other plants. It is a white crystalline solid that is practically insoluble in water, soluble in diethyl ether, and slightly soluble in ethanol 1tetradecanol may be prepared by the hydrogenation of myristic acid or its esters. General description sperillyl alcohol is a monoterpenoid compound found in the essential oils of cherries, lavender and spearmint. Safety data sheet 70% isopropyl rubbing alcohol section 1. Box 697, osprey, florida, 342290697 941 3779935 fax 941 3779539 cas number 67630. It has character with odors of purple perilla, cinnamic aldehyde and cumin aldehyde scent. Search results for perillyl alcohol at sigmaaldrich. Foreverest perilla aldehyde perillaldehyde is a synthesis of betapinene, appears colorless to pale yellow liquid. Packaging 1 kg in poly bottle 100 g in poly bottle 5 kg in poly drum other notes download our flavors and fragrances catalog to view our entire product line.
Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing posttranslational protein farnesylation and isoprenylation and activation of oncoproteins such as p21ras, and arresting tumor cells in the g1 phase of the cell cycle. Name perillyl alcohol description perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. Metabolic engineering of escherichia coli for limonene and. Flush eyes with large amounts of water for at least 15 minutes. Product and company identification 70% isopropyl alcohol product code. A specific form of perillyl alcohol may be helpful in palliative care patients with recurrent gliomas. Packaging 10, 50 g in glass bottle other notes tandem mass spectrometry data independently generated by scripps center for metabolomics is available to view or download in pdf. Perillyl alcohol exhibits neuroprotective, antioxidative, antiinflammatory, antiasthma, antiallergic, immunomodulatory, anticancer chemotherapeutic, and chemopreventive activities. Perillyl alcohol is a monoterpene derived from lavender, that induces apoptosis in colon tumor cells. Inhibits mammary cancer by inducing hepatocyte phase ii enzymes, glutathionestransferase. Accessible at medicor see below or it can be ordered from chemical suppliers under the cas 18457551. Description, perillyl alcohol is a monoterpene isolated from the essential oils of. Comparison between the specific rotation of commercial s.
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